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Results for "

thiol group

" in MedChemExpress (MCE) Product Catalog:

42

Inhibitors & Agonists

14

Fluorescent Dye

10

Biochemical Assay Reagents

1

Natural
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12

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-137541
    2-Nitro-5-thiocyanatobenzoic acid

    NTCB

    		 Biochemical Assay Reagents Others
    2-Nitro-5-thiocyanatobenzoic acid (NTCB) is a highly reactive reagent that transfers its cyano group rapidly to a nucleophilic thiolate. 2-Nitro-5-thiocyanatobenzoic acid has been proposed as a reagent for converting thiol groups in proteins into their S-cyano derivatives .
    2-Nitro-5-thiocyanatobenzoic acid
  • HY-D1526
    N-(4-Anilino-1-naphthyl)maleimide

    		Fluorescent Dye Others
    N-(4-Anilino-1-naphthyl)maleimide is a fluorescent probe that can be used to detect thiol groups in proteins. N-(4-Anilino-1-naphthyl)maleimide reacts with thiol groups and immediately produces a stable fluorescent compound with the λex=355 nm, λem=448 nm .
    N-(4-Anilino-1-naphthyl)maleimide
  • HY-D1654
    BDP 581/591 maleimide

    		Fluorescent Dye Others
    BDP 581/591 maleimide is a linker of the BDP 581/591 dye. It has a long fluorescence lifetime and can be used for fluorescence polarization assays. The maleimide group can react with thiol groups to form thioester bonds between pH 6.5 to 7.5, for the labeling of sulfhydryl groups of proteins and peptides.
    BDP 581/591 maleimide
  • HY-W013754
    S-Hexylglutathione

    		Others Others
    S-Hexylglutathione is an S-substituted glutathione in which the hydrogen of the thiol has been replaced by a hexyl group. S-Hexylglutathione is also an competitive inhibitor against glutathione-S-transferase. S-Hexylglutathione can be used as an affinity chromatographic ligand for glutathione-S-transferase and glutathione peroxidase .
    S-Hexylglutathione
  • HY-156377
    Biotin-PEG7-Maleimide

    		Drug-Linker Conjugates for ADC Cancer
    Biotin-PEG7-Maleimide is a biotinylation reagent that reacts with thiol groups (SH). Biotin-PEG7-Maleimide can be used as Drug-Linker Conjugates for ADCs .
    Biotin-PEG7-Maleimide
  • HY-W441004
    DSPE-Thiol

    		Liposome Others
    DSPE-Thiol is a phophalipid capped with thiol group. The thiol capped head can selectively react with maleimide. DSPE-Thiol can also be used for the preparation of phospholipid dimers .
    DSPE-Thiol
  • HY-116427
    Propargyl-PEG4-thiol

    		ADC Linker PROTAC Linkers Cancer
    Propargyl-PEG4-thiol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-thiol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG4-thiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-thiol
  • HY-138525
    Azido-PEG4-Thiol

    		PROTAC Linkers Cancer
    Azido-PEG4-Thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG4-Thiol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Azido-PEG4-Thiol
  • HY-162159
    Ac-Cys-NHMe

    		Others Others
    Ac-Cys-NHMe is a Cys dipeptide with thiol group .
    Ac-Cys-NHMe
  • HY-136130
    N,N-Bis(PEG2-alkyne)-N-amido-PEG2-thiol

    		ADC Linker Cancer
    N,N-Bis(PEG2-alkyne)-N-amido-PEG2-thiol is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N,N-Bis(PEG2-alkyne)-N-amido-PEG2-thiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N,N-Bis(PEG2-alkyne)-N-amido-PEG2-thiol
  • HY-135133
    S-Phenylsulfonylcysteine

    		Biochemical Assay Reagents Others
    S-Phenylsulfonylcysteine is a reagent for blocking thiol (-SH) groups on proteins and peptides .
    S-Phenylsulfonylcysteine
  • HY-134428
    Arachidonoyl coenzyme A lithium

    		Endogenous Metabolite Metabolic Disease
    Arachidonoyl coenzyme A lithium is an unsaturated fatty acyl coenzyme A, formed by the condensation of the thiol group of coenzyme A with the carboxyl group of arachidonic acid .
    Arachidonoyl coenzyme A lithium
  • HY-136129
    N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol

    		ADC Linker Cancer
    N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol
  • HY-15915
    DTNB
    3 Publications Verification

    Ellman’s Reagent

    		 Biochemical Assay Reagents Others
    DTNB (Ellman’s Reagent) is a chemical used to quantify the number or concentration of thiol groups .
    DTNB
  • HY-D0042
    NBD-Cl
    1 Publications Verification

    NBD chloride

    		 Fluorescent Dye Others
    NBD-Cl is a nonfluorescent reagent which becomes highly fluorescent after reaction with thiol or amino groups .
    NBD-Cl
  • HY-D1363
    BDP R6G maleimide

    		Fluorescent Dye Others
    BDP R6G maleimide is a borodipyrromethane fluorophore with absorption and emission wavelengths similar to those of R6G rhodamine. Sulfhydryl labelling is a common protein modification where the cysteine residues in the protein allow more site-specific labelling than the NHS ester of the amine group. BDP R6G maleimide is a thiol reactive dye that reacts with thiol groups to form thioester bonds .
    BDP R6G maleimide
  • HY-D2089
    PE-VF594 Maleimide

    		Fluorescent Dye Others
    PE-VF594 Maleimide is a double-dye dye that can undergo thiol reaction. It contains maleimide groups that can react with thiol groups to form covalent bonds. PE-VF594 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 617 nm.
    PE-VF594 Maleimide
  • HY-D2091
    PE-VF647 Maleimide

    		Fluorescent Dye Others
    PE-VF647 Maleimide is a double-dye dye that can undergo thiol reaction. It contains maleimide groups that can react with thiol groups to form covalent bonds. PE-VF647 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 665 nm.
    PE-VF647 Maleimide
  • HY-D2093
    PE-VF750 Maleimide

    		Fluorescent Dye Others
    PE-VF750 Maleimide is a thiol-reactive double-dye dye that contains maleimide groups that can react with thiol groups to form covalent bonds. Ex/Em=495-566/777 nm. PE-VF750 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 777 nm.
    PE-VF750 Maleimide
  • HY-130080
    DM3

    Maytansinoid DM3

    		 ADC Cytotoxin Microtubule/Tubulin Cancer
    DM3 (Maytansinoid DM3) is a maytansine analog bearing disulfide or thiol groups and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs) .
    DM3
  • HY-136386
    N-Acetyl-D-cysteine
    2 Publications Verification

    		 Reactive Oxygen Species Others
    N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway .
    N-Acetyl-D-cysteine
  • HY-D2092
    PE-VF680 Maleimide

    		Fluorescent Dye Others
    PE-VF680 Maleimide is a double-dye dye that can undergo thiol reaction. It contains maleimide groups that can react with thiol groups to form covalent bonds. Ex/Em=495-566/701 nm. PE-VF680 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 701 nm.
    PE-VF680 Maleimide
  • HY-135233
    N-Succinimidyl-S-acetylthioacetate

    SATA

    		 Biochemical Assay Reagents Others
    N-Succinimidyl S-acetylthioacetate (SATA), a protein modification agent, introduces thiol-groups into protein molecules. N-Succinimidyl S-acetylthioacetate adds sulfhydryl groups to proteins and other amine-containing molecules in a protected form .
    N-Succinimidyl-S-acetylthioacetate
  • HY-W020780A
    mPEG-Mal (MW 350)

    mPEG-Maleimide (MW 350); Methoxypolyethylene glycol maleimide (MW 350)

    		 Biochemical Assay Reagents Liposome Others
    mPEG-Mal (MW 350) is a PEG derivative used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
    mPEG-Mal (MW 350)
  • HY-W020780B
    mPEG-Mal (MW 750)

    mPEG-Maleimide (MW 750); Methoxypolyethylene glycol maleimide (MW 750)

    		 Biochemical Assay Reagents Liposome Others
    mPEG-Mal (MW 750) is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
    mPEG-Mal (MW 750)
  • HY-W020780C
    mPEG-Mal (MW 3400)

    mPEG-Maleimide (MW 3400); Methoxypolyethylene glycol maleimide (MW 3400)

    		 Biochemical Assay Reagents Liposome Others
    mPEG-Mal (MW 3400) is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
    mPEG-Mal (MW 3400)
  • HY-Y1147
    Diethyl maleate

    Maleic acid diethyl ester
    Diethyl maleate is a maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. Diethyl maleate (DEM), a thiol-reactive α,β-unsaturated carbonyl compound, depletes glutathione (GSH) in exposed cells .
    Diethyl maleate
  • HY-156391A
    (R)-TCO4-PEG2-Maleimide

    		PROTAC Linkers Cancer
    TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
    (R)-TCO4-PEG2-Maleimide
  • HY-156392
    TCO4-PEG7-Maleimide

    		PROTAC Linkers Cancer
    TCO4-PEG7-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG7-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
    TCO4-PEG7-Maleimide
  • HY-W872575A
    (R)-TCO4-PEG3-Maleimide

    		PROTAC Linkers Cancer
    TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
    (R)-TCO4-PEG3-Maleimide
  • HY-156391
    TCO4-PEG2-Maleimide

    		PROTAC Linkers Cancer
    TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
    TCO4-PEG2-Maleimide
  • HY-W872575
    TCO4-PEG3-Maleimide

    		PROTAC Linkers Cancer
    TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
    TCO4-PEG3-Maleimide
  • HY-D2150
    AF 430 maleimide

    		Fluorescent Dye Others
    AF 430 maleimide is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 430 nm and an emission wavelength of 542 nm. AF 430 maleimide contains maleimide groups that react with thiol groups to form covalent bonds. To achieve specific coupling of dye labels and biomolecules.
    AF 430 maleimide
  • HY-155901
    Mal-NH-PEG-NH2 TFA (MW 2000)

    Maleimide-NH-PEG-amine TFA (MW 2000)

    		 Liposome Others
    Mal-NH-PEG-NH2 (TFA) (MW 2000) is a PEG derivative that may be used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
    Mal-NH-PEG-NH2 TFA (MW 2000)
  • HY-E70254
    Tricosanoyl-CoA triammonium

    		Others Others
    Tricosanoyl-CoA triammonium is a very long-chain fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A (HY-128851) with the carboxy group of tricosanoic acid (HY-W009081). Tricosanoyl-CoA is functionally related to a tricosanoic acid. Tricosanoyl-CoA is a conjugate acid of a tricosanoyl-CoA(4-).
    Tricosanoyl-CoA triammonium
  • HY-D2094
    PerCP Maleimide

    		Fluorescent Dye Inflammation/Immunology Cancer
    PerCP Maleimide is a fluorescent dye that reacts with free sulfhydryl groups on proteins. PerCP is a red fluorescence albuminous dye for immunostaining and Maleimide can be leveraged for the preparation of fluorogenic probe, which is mainly used for the specific detection of thiol analytes .
    PerCP Maleimide
  • HY-W440896
    DSPE-PEG-SH, MW 2000

    		Liposome
    DSPE-PEG-SH, MW 2000 is a pegylated phospholipid with thiol group which is reactive with maleimide to form a covalent thioether linkage. The amphiphatic polymer can form lipid bilayer in aqueous solution and be used to encapsulate agents for drug delivery system, such as mRNA vaccine.
    DSPE-PEG-SH, MW 2000
  • HY-D1260
    FM-red

    PSH-red

    		 Fluorescent Dye Neurological Disease
    FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx) .
    FM-red
  • HY-W879048
    DBCO-PEG24-Maleimide

    		ADC Linker Others
    DBCO-PEG24-Maleimide contains a maleimide and a DBCO group. DBCO-PEG24-Maleimide can be used for thiol-containing biomolecule conjugations. DBCO-PEG24-Maleimide can be used in click chemistry with azide-bearing biomolecules .
    DBCO-PEG24-Maleimide
  • HY-D1404
    5MP-Propargyl

    		Fluorescent Dye Others
    5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . 5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    5MP-Propargyl
  • HY-D1871
    Cy3 maleimide chloride

    		Fluorescent Dye Others
    Cy3 maleimide chloride is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing maleimide functional groups. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The alkyne functional group of Cy3 maleimide chloride can undergo a "thiol-acrylamide" reaction with molecules containing sulfur-oxygen functional groups to form covalent bonds. Cy3 maleimide chloride can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
    Cy3 maleimide chloride
  • HY-D1407
    Br-5MP-Propargyl

    		Fluorescent Dye Others
    Br-5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . Br-5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Br-5MP-Propargyl

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